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In order to control cAMP build-up Tregs as well as T cells utilize anenzyme called phosphodiesterase (PDE) to catalyze the hydrolysis cAMP into 5‘ –AMP(Gancedo 2013).

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However, as discussed below, in cell culturestudies MDM2 has been found to regulate crucial cell cycle regulatory genes innormal cells [ 24 – 26].

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